The easiest way to cope with sperm allergy is to make sure there is no contact with semen. Couples are usually advised to use condoms every time they have sex. Or, they may engage in coitus interruptus, in which the man removes his penis from the vagina before he ejaculates.
Another option is called intravaginal seminal graded challenge. In this procedure, an allergist places diluted amounts of the partner’s semen into the woman’s vagina every 20 minutes, gradually increasing the amount of semen until she can tolerate the pure semen. Couples who choose this route are instructed to have sex every 48 hours to maintain this level of tolerance.
As a precaution, many women with sperm allergy are prescribed an epinephrine auto-injector, or EpiPen, in case anaphylaxis, a life-threatening allergic reaction, occurs.