Peyronie’s Disease and Grafts: What is a graft? Reviewed by the medical professionals of the ISSM’s Communication Committee A graft is tissue that is transplanted, often from another part of the body. For example, tears in the skin or damaged blood vessels may be repaired with grafts. Problems with bones and gums can be treated with grafts, too. Next question: How can grafts help men with Peyronie’s disease?Previous question: How is Peyronie’s disease diagnosed?